Endocrine Abstracts

In some patients with Cushing’s disease (CD), magnetic resonance imaging (MRI) fails to detect small pituitary ACTH-secreting adenomas despite the results of endocrine evaluation indicating Cushing’s disease.Aim: The aim of this paper is to study frequency of hypocorticism after radiosurgery – protonotherapy (PT) for patients with normal MRI for Cushing’s disease and for patients with confirmed adenomas.Methods:...

It is known from the literature that primary empty sella syndrome (PES) and secondary empty sella syndrome (SES) are distinguished. Empty sella syndrome is a radiographic finding characterized of a herniation of suprasellar cistern into the sella turcica. SES is a result of influence of surgery or radial therapy on hypothalamic-pituitary area. The aim of our study was a comparison the clinical features of primary and secondary empty sella syndrome.Fifty ...

Transsphenoidal surgery is the treatment of choice in acromegaly. However, some patients do not achieve postoperative remission. The aim of our study was to identify factors that predictive of a poor surgical outcome in patients with acromegaly. In our study we included 39 acromegalic patients, who underwent transsphenoidal surgery as initial treatment. We evaluated clinical, hormonal and radiological predictors based on magnetic resonance imaging (MRI). Also we examined immun...

The degree of hormonal activity and the duration of active phase of disease are the most important factors in the pathogenesis of system complications, decreasing life span in patients with acromegaly. To determine the age-related features of the clinical course of disease 140 patients with active acromegaly were examined. All patients were divided into 3 groups: group 1 included 14 patients at the age of 20–39, group 2 – 40–59 (72) and group 3 – ≥60 ...

Androgens play an important part in follicular development, sexual behavior, maintenance of skeletal homeostasis, normal affect and cognitive function. The negative influence of androgen deficiency is widely discussed in postmenopausal women. However, there is a cohort of young women with gonadal steroid deficit caused by the disorders of central regulation. It is well known that these patients are in lack of estrogens however their androgen status is not detailed.<p class...